Pefloxacin in adriamycin induced nephrotic syndrome in the rat
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چکیده
منابع مشابه
Pefloxacin in adriamycin induced nephrotic syndrome in the rat.
BACKGROUND Pefloxacin, a fluorinated 4-quinolone, has recently been advocated as a first-line treatment for minimal-change nephropathy (MCN) or focal segmental glomerulosclerosis (FSGS). To further evaluate this issue we have utilized an animal model resembling human MCN, namely adriamycin-induced nephrotic syndrome in Wistar male rats. METHODS Adriamycin at a dose of 7 mg/kg was injected int...
متن کاملEfficacy of deferoxamine, N-acetylcysteine and selenium treatments in rats with Adriamycin-induced nephrotic syndrome.
BACKGROUND Various experimental models related to Adriamycin (ADR)-induced nephropathy have been reported. The purpose of the present study was to evaluate the efficacy of N-acetylcysteine (NAC), deferoxamine (DFO) and selenium in protection against renal injury in ADR nephropathy. METHODS The study included 53 Sprague Dawley male rats. Nephrotic syndrome was induced by injection of ADR 5 mg/...
متن کاملEffect of atrial natriuretic factor on renal cGMP production in rats with adriamycin-induced nephrotic syndrome.
Adriamycin-induced nephrotic syndrome in the rat is associated with a blunted natriuretic response to infusion of atrial natriuretic factor. To study the mechanism of renal hyporesponsiveness to the peptide in rats with experimental nephrosis, we evaluated the effects of the hormone on renal production of cGMP, the second messenger of the hormone. Baseline GFR and sodium excretion were lower in...
متن کاملNAC attenuates adriamycin-induced nephrotic syndrome in rats through regulating TLR4 signaling pathway.
OBJECTIVE Nephrotic syndrome (NS) is a detrimental renal disease that affects a large population. It is suggested that Toll-like Receptor 4 (TLR4) signaling pathway plays an important role in NS. The aim of this study was to evaluate the immunosuppressive effect of N-acetylcysteine (NAC) in the treatment of NS elucidate its interaction with TLR4 pathway in a rat model. MATERIALS AND METHODS R...
متن کاملEarly treatment with everolimus exerts nephroprotective effect in rats with adriamycin-induced nephrotic syndrome.
BACKGROUND Nephrotic syndrome (NS) is a clinical state characterized by massive proteinuria and excessive fluid retention. The effects of early versus late treatment with low or high doses of oral everolimus, a mammalian target of rapamycin inhibitor, on proteinuria in NS have not been previously described. METHODS The effects of early treatment (2 days prior to NS induction) versus late trea...
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ژورنال
عنوان ژورنال: Nephrology Dialysis Transplantation
سال: 1997
ISSN: 0931-0509,1460-2385
DOI: 10.1093/ndt/12.2.286